Syntheses of C2′-Fluorinated Analogs of Solamin

Syntheses of C2-symmetric vicinal diamines derived from tartaric acid

C2-symmetric vicinal diamines 3b–f, derived from L-tartaric acid, with increasingly bulky terminal ether functionalities were prepared using two distinct sequences. Diamines 3b,c were obtained from the corresponding vicinal diols 4b,c, while diamines 3d–f were generated from dihydroxydiazide 7 via deprotection–reprotection strategies. © 1999 Elsevier Science Ltd. All rights reserved.

Fluorinated analogs of malachite green: synthesis and toxicity.

A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem to be the most promising analogs because they showed th...

Continued Progress Towards Efficient Syntheses Of Cephalostatin North 1 Analogs

Jamieson, Daniel P. Ph.D., Purdue University, December 2013. Continued Progress Towards Efficient Syntheses of Cephalostatin North 1 Analogs. Major Professor: Philip L. Fuchs. The cephalostatins and ritterazines represent an intriguing class of marine natural products in both structure and biological activity, and the progress towards the synthesis of high valued analogs with a focus on process...

Expeditious syntheses of two carbohydrate-linked cisplatin analogs.

The syntheses of two carbohydrate-linked cisplatin analogs, namely lacto- and alpha-Gal-cisplatin, are described. A fusion enzymatic approach was used to create the diazido-alpha-Gal trisaccharide intermediate in the synthesis of alpha-Gal-cisplatin.

Syntheses and enzyme inhibiting activities of cyclophellitol analogs.